Respectfully, engineering is inapplicable, if not outright inappropriate to human metabolism. Yes, calories in- calories out is absolutely true.
But humans are not closed systems. There is nothing more complex and involves more combinations of metabolic, neurological hormones, chemistry, thermodynamics and even variable bio-mechanical factors such as the differing lengths of everyones small intestine. Those skinny bastards and bitches often have a shorter than average small intestine and therefore absorb less calories and shit more down the toilet. Evolutionarily superior humans have longer than average small intestines and therefore take up more calories of whatever they put in their mouths. They can survive famine longer due to their superior ability to not shit out valuable calories.
This is the foundation of bariatric weight loss surgery. Surgically engineered and reduction/bypass of most of the small intestine resulting in malabsorption.
The UPMC Bariatric Surgery Center offers multiple malabsorptive surgery options to help with your weight loss. Learn more about the procedures available.
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- Malabsorptive bariatric surgery limits the amount of nutrients the body absorbs by bypassing a portion of the small intestine.
Having said that, sugar and high carb diets can thwart even highly restrictive malabsorptive procedures.