en.wikipedia.org
Okay, Mr SMFH. We're going to go through some more scientific articles. Let's start with the Wiki article on Ivermectin. Your bud Oracle says that Ivermectin is a protease inhibitor. That's not what the wiki article says. Let's read it together, shall we?
Pharmacology
Ivermectin (IVM) bound to a
C. elegans GluClR. IVM molecules interact with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl−) ions into the cell. (The plasma membrane is represented as a blue–pink gradient.) From
PDB:
3RHW.
Mechanism of action
Ivermectin and its related drugs act by interfering with the nerve and muscle functions of
helminths and insects.
[61] The drug binds to
glutamate-gated
chloride channels common to invertebrate nerve and muscle cells.
[62] The binding pushes the channels open, which increases the flow of
chloride ions and hyper-polarizes the cell membranes,
[61] paralyzing and killing the invertebrate.
[62] Ivermectin is safe for mammals (at the normal therapeutic doses used to cure parasite infections) because mammalian glutamate-gated chloride channels only occur in the brain and spinal cord: the causative avermectins usually do not cross the
blood–brain barrier, and are unlikely to bind to other mammalian
ligand-gated channels.
[62]
I'm not reading "protease inhibitor" there. I'm reading that it paralyzes little crawly fuckers. You want to tell me where you get "protease inhibitor", I'm happy to read it. But I can't find it anywhere in the Wiki article.
Here is more Wiki:
COVID-19 misinformation
Further information:
COVID-19 misinformation § Ivermectin
Ivermectin has been pushed by right-wing politicians and activists promoting it as a supposed COVID treatment.
[83][84][85] Misinformation about ivermectin's efficacy spread widely on social media, fueled by publications that have since been retracted,
[86][87] misleading "
meta-analysis" websites with substandard methods,
[88][89] and conspiracy theories about efforts by governments and scientists to "suppress the evidence."
[90][91]
In response to widespread misuse, the U.S.
Food and Drug Administration, U.S. Centers for Disease Control, World Health Organization,
American Medical Association,
American Pharmacists Association, and
American Society of Health-System Pharmacists issued statements in 2021 warning that ivermectin is not approved or authorized for the treatment or prevention of COVID-19, and advised against its use for that purpose outside of clinical trials.
[60][22][92]
On September 1, 2021, health experts from the United States expressed concerns from reports of sharp increases in outpatient prescribing and dispensing of ivermectin with respect to levels before the pandemic.
[93] These experts explain that the CDC has not authorized or approved ivermectin for the prevention or treatment of COVID-19. The
American Association of Poison Control Centers has reported 1,440 cases of ivermectin poisoning through September 20, 2021, a three-fold increase compared to similar time periods in 2019 and 2020.
[94]
Here is another chunk of Wiki for you:
en.wikipedia.org
Ivermectin
Further information:
COVID-19 drug repurposing research § Ivermectin
The
antiparasitic drug
ivermectin became a
cause célèbre for right-wing figures promoting it as a supposed COVID treatment.
[401] Misinformation about ivermectin's efficacy spread widely on social media, fueled by publications that have since been retracted,
[402][403] misleading "
meta-analysis" websites with substandard methods,
[404][405] and conspiracy theories about efforts by governments and scientists to "suppress the evidence."
[406][407]
In October 2021 a large network of companies selling hydroxychloroquine and ivermectin has been disclosed in the US, targeting primarily right-wing and vaccine hesitant groups through social media and conspiracy videos by anti-vaccine activists such as
Simone Gold. The network had 72,000 customers who collectively paid $15 million for consultations and medications.
[408]
Regulatory status and off-label use
Ivermectin is not approved by the U.S.
Food and Drug Administration (FDA) for use in treating any viral illness and is not authorized for use to treat COVID-19 within the European Union.
[409] After reviewing the evidence on ivermectin, the EMA said that "the available data do not support its use for COVID-19 outside well-designed clinical trials".
[409] The WHO also said that ivermectin should not be used to treat COVID-19 except in a clinical trial.
[410] The
Brazilian Health Regulatory Agency, Brazilian Society of Infectious Diseases, and Brazilian Thoracic Society issued position statements advising against the use of ivermectin for prevention or treatment of early-stage COVID-19.
[411][412][413]
Misinformation, lower degrees of
trust, and a sense of despair over increasing case and death counts has led to an increase in ivermectin's use in Central and Eastern Europe, Latin America,
[414][415] and South Africa. A black market has also developed in many of these countries where official approval has not been granted.
[416]
Several
Latin American government health organizations recommended ivermectin as a COVID-19 treatment based, in part, on preprints and anecdotal evidence; these recommendations were later denounced by the
Pan American Health Organization.
[402][417]
The viral social media misinformation about ivermectin has gained particular attention in South Africa where an anti-vaccination group called "South Africa Has A Right To Ivermectin" has been lobbying for the drug to be made available for prescription.
[418] Another group, the "Ivermectin Interest Group" launched a court case against the
South African Health Products Regulatory Authority (SAHPRA), and as a result a
compassionate use exemption was granted. SAPHRA stated in April 2021 that "At present, there are no approved treatments for COVID-19 infections."
[418]
Despite the absence of high-quality evidence to suggest any efficacy and advice to the contrary, some governments have allowed its
off-label use for prevention and treatment of COVID-19. Countries that have granted such official approval for ivermectin include the Czech Republic,
[416] Slovakia,
[416] Mexico,
[419] Peru (later rescinded),
[420][421] India
[422][423] (later rescinded),
[424] the Philippines,
[425] and the Colombian city of Cali.
[426]
In
Washington County, Arkansas, Dr. Robert Karas was criticized for prescribing ivermectin for COVID-19 prevention against FDA guidance, for himself, for his family, and for prison employees and inmates at the Washington County Detention Center in
Fayetteville, Arkansas. His company, Karas Correctional Health, prescribed at least one corrections officer vitamins and ivermectin after a negative COVID-19 test.
[427]
High-profile retractions and misleading websites
Several high-profile publications purporting to demonstrate reduced mortality in COVID-19 patients were later retracted due to suspected data falsification.
[428][429] This only added to confusion among the media and lay public,
[402] as these publications had been widely cited by ivermectin supporters and included in meta-analyses.
[403][401][430]
During the pandemic, a number of misleading websites appeared purporting to show meta-analyses of clinical evidence in favor of ivermectin's use in treating COVID-19.
[404][405] The sites in question had anonymous owners, multiple domains which redirected to the same content, and used many colorful, but misleading, graphics to communicate their point.
[431][404] The web servers used for these sites are the same as those previously used to spread misinformation about
hydroxychloroquine.
[432]
While these sites gained traction among many non-scientists on social media, they also violated many of the basic norms of meta-analysis methodology. Notably, many of these sites included studies with widely different dosages of the treatment, an
open-label design (in which experimenters and participants both know who is in the control group), poor-quality
control groups (such as another untested treatment which may worsen outcomes), or no control group at all.
[405] Another issue is the inclusion of multiple ad-hoc un-published trials which did not undergo
peer-review, and which had different incompatible
outcome measures.
[433] Such methodological problems are known to distort the findings of meta-analyses and cause spurious or false findings.
[434] The misinformation communicated by these sites created confusion among the public and policy makers.
[404]
Frontline COVID-19 Critical Care Alliance (FLCCC)
Holy shit, LolRus! I'm not reading anything about Ivermectin being a "protease inhibitor" on THAT wiki either. You want to tell me where you got the "protease inhibitor" info. You show me, I'll read it.
In fact - from my brief little amble through a couple of Wiki pages - Ivermectin appears to have nothing to do with "protease inhibitor" stuff and the Pfizer research appears to be brand new. Which kinda makes sense in a way that your and Oracle's theory really doesn't - for all the reasons I listed above when you did your little "SMFH" shtick at me.
Looking forward to either you or Oracle responding to this. I'd like to see you cite some scientific articles at me - even basic shit like Wiki. You and I have some talking to do.
