man its vegas, you can do whatever you want there. I've been about a dozen times, did not regret one trip and plan on going back again soon.
for me I like to line up a couple shows (any of the cirque shows are amazing), do a bit of gambling, hit a bunch of world class restaurants, do some drinking and partying...but whatever turns your crank.
I plan on checking out rehab at the hard rock next time I am there. looks like an amazing place.
have fun