they are genetic anomalies, which are abnormal. its a very small slice of the population. where as, most people who identify as trans don not have genetic abnormalities. typically people with downs either have a penis and are male, and a vagina and a female.Huh, so what gender are people with down syndrome?
there are also men with an extra y as well. also a genetic anomaly. havng the extra y doesnt make them extra men. they tend to have more aggressive tendencies and other attributes.