My hair is OK despite my age, so I've never used anything to slow any loss.
Here's a copy and paste of the New York Times article...
An Old Medicine Grows New Hair for Pennies a Day, Doctors Say
Dermatologists who specialize in hair loss say that the key ingredient in a topical treatment worked even better when taken orally at a low dose.
Minoxidil in topical form is not particularly effective for some patients who report disliking leaving the substance in their hair, then stop taking it. But the results are different when taken orally.
By
Gina Kolata
Aug. 18, 2022
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The ads are everywhere — and so are the inflated claims: Special shampoos and treatments, sometimes costing thousands of dollars, will make hair grow. But many dermatologists who specialize in hair loss say that most of these products don’t work.
“There is an endless array of useless hair growth remedies,” often at “significant cost,” said Dr. Brett King, a dermatologist at Yale School of Medicine. Yet, he added, “because people are desperate, such hair growth remedies continue to abound.”
But there is a cheap treatment, he and other dermatologists say, costing pennies a day, that restores hair in many patients. It is minoxidil, an old and well-known hair-loss treatment drug used in a very different way. Rather than being applied directly to the scalp, it is being prescribed in very low-dose pills.
Although a growing group of dermatologists is offering low-dose minoxidil pills, the treatment remains relatively unknown to most patients and many doctors. It has not been approved by the Food and Drug Administration for this purpose and so is prescribed off-label — a common practice in dermatology.
“I call us the off-label bandits — a title I am proud to bear,” said Dr. Adam Friedman, professor and chair of dermatology at George Washington University. He explained that dermatologists have been trained to understand how medicines work, which allows them to try drugs off-label. In dermatology, it is often clear if a treatment is helping. Does a rash fade, or not?
Dr. Robert Swerlick, professor and chair of the dermatology department at Emory University School of Medicine, agreed.
“I tell people most things we do are off-label because there is nothing on-label,” he said. He provided a long list of conditions, including skin pigment disorders, skin inflammatory disorders and relentless itching, for which the standard treatments are off-label.
Minoxidil, the active ingredient in Rogaine, a lotion or foam that is rubbed on the scalp, was first approved for men in 1988, then women in 1992, and it is now generic. The medicine’s use as a hair-growth treatment was
discovered by accident decades ago. High-dose minoxidil pills were being used to treat high blood pressure, but patients often noticed that the pills prompted hair growth all over their bodies. So its manufacturer developed a minoxidil lotion — eventually named Rogaine — and got it approved to grow hair on balding heads.
But dermatologists say the lotion or foam is not particularly effective for some patients, perhaps because they stop taking it. It has to get on the scalp itself — and hair gets in the way. Many, especially women, stop using it because they dislike leaving the sticky substance in their hair.
Johnson and Johnson, the current owner of Rogaine, did not respond to requests for comment.
Others find it simply does not work for them.
Minoxidil has to be converted to an active form by sulfotransferase enzymes that may or may not be present in sufficient quantities in hair roots. When the drug is taken orally, it is automatically converted to an active form.
But that was not the reason the low-dose pills were discovered. Instead, the discovery occurred also by accident 20 years ago.
Dr. Rodney Sinclair, a professor of dermatology at the University of Melbourne in Australia, had a patient with female pattern baldness. The hair on top of her head had thinned, and she hated the way it looked. Unlike what happened with most of his patients, Rogaine worked for her, but she developed an allergic rash on her scalp from the drug. Yet if she stopped taking it, her hair would thin again.
“So I was stuck,” Dr. Sinclair said. “The patient was very motivated, and the one thing we knew was that if a patient has an allergy to a topically applied medicine, one way to desensitize is to give very low doses orally.”
To do that, Dr. Sinclair tried cutting minoxidil pills into quarters. To his surprise, the low dose made her hair grow but did not affect her blood pressure, the original purpose of the higher-dose drug.
He subsequently lowered the dose more and more until he got down to effective doses of one-fortieth of a pill and began routinely prescribing the drug. That first patient still takes it.
At a
meeting in Miami in 2015, Dr. Sinclair reported that low doses of minoxidil prompted hair growth in 100 successive women.
He
published those results in 2017, noting that rigorous studies were needed, in which some patients would be randomly assigned to take minoxidil and others a sugar pill. But that has not happened. He says he has now treated more than 10,000 patients.
Recently, a rising number of hair-loss dermatologists have been giving the low-dose pills to patients with male and female pattern hair loss, a normal occurrence with age.
Brandy Gray, 44, was seen by Dr. Crystal Aguh before and after treatment with oral minoxidil.Credit...Crystal Aguh/Johns Hopkins School of Medicine
“It is just starting to see a surge in popularity,” said Dr. Crystal Aguh, a dermatologist at Johns Hopkins School of Medicine. “More and more at conferences, we are sharing our success stories.”
Doctors who do not specialize in hair loss, she added, “would not be familiar with oral minoxidil,” except as a rarely used treatment for high blood pressure that comes with a black box warning that it can cause heart problems. But, she and others say, the warning is for much higher doses.
If hair loss is too severe, minoxidil will not help, Dr. Aguh warned. “It will not work, for example, if a man is mostly bald, with a shiny scalp. There is nothing to restore.” She added that the ideal patient is not completely bald but has lost enough hair that even a casual observer would notice.
Without a rigorous trial leading to F.D.A. approval, though, the use of minoxidil pills for hair loss remains off-label. And, dermatologists say, it is likely to remain so.
“Oral minoxidil costs pennies a day,” Dr. King said. “There is no incentive to spend tens of millions of dollars to test it in a clinical trial. That study truly is never, ever going to be done.”
Some patients taking low-dose minoxidil, though, notice stray hairs growing on their faces and chins. So some dermatologists, including Dr. Sinclair, have added another drug — very low doses of spironolactone, a blood pressure drug that also blocks certain sex hormones called androgens — to try to prevent unwanted hair growth.
Patients who do not want to go the off-label route are left with what some dermatologists say are useless over-the-counter remedies or one of two F.D.A.-approved products for hair growth.
They include Rogaine and finasteride, a generic medicine used at higher doses in men to treat a benign enlarged prostate. As a hair-loss drug, it is approved for men only. It has also been linked to sexual dysfunction.
Then, there is the word of mouth about minoxidil in pill form.
“I’ve seen miracles happen,” Dr. Aguh said.
One involved Brandy Gray, 44, who lives in Monkton, Md.
“I had been losing my hair over time,” she said. “Then I starting having circular patches” with no hair. “They got worse and worse.”
She had seen another dermatologist who gave her shampoos and supplements, to no avail. Finally, she said her dermatologist told her, “There is nothing left I can try for you, nothing more I can do.”
She went to Dr. Aguh who gave her low-dose minoxidil. Ten months later, her hair was thick and abundant.
“I can part my hair in different ways,” she said. “I don’t wear wigs any more.”
It is as though that hair loss never happened.
Gina Kolata writes about science and medicine. She has twice been a Pulitzer Prize finalist and is the author of six books, including “Mercies in Disguise: A Story of Hope, a Family's Genetic Destiny, and The Science That Saved Them.”
A version of this article appears in print on Aug. 23, 2022, Section D, Page 3 of the New York edition with the headline: In a Different Form, Minoxidil Can Produce ‘Miracles’.
