Hi. depends on where you are. here are a few recommendations that are out of the ordinary. since i am sure you already heard of all the international hotels.
Gladstone Hotel is a designer boutique hotel with theme
http://www.gladstonehotel.com/
Cosmopolitan is also a boutique and spa hotel with the ZEN style
http://www.cosmotoronto.com/
Pantages is same company as cosmo, so also a boutique & spa hotel.
http://www.pantageshotel.com/
If you're up north, try this slightly cheaper hotel.
Monte Carlo Inns - don't underestimate this place. they have extremely nice in room jacuzzi. Depends on which style you book, it can be a huge bathroom with a huge jacuzzi in the middle surrounded by mirrors or it can be jacuzzi not in the bathroom but right beside your bed or even jacuzzi that surrounded by Roman style columns. check out the photo gallery & Virtual tour and see for yourself.
http://www.montecarloinns.com/markhamguestrooms.html