Getting hydroxychloroquine

[PornAddict]

Does this settle the question about the efficacy of the anti-malaria drug in treating COVID-19?



https://www.scmp.com/news/china/sci...tment-hailed-trump-has-no-benefit-coronavirus

Here another thread probably the came from the same French study I suspect!

COVID-19: Brazilian trial for drug touted by Trump halted after 11 patients die——> misleading article title

A more accurate title would be~~~>

COVID-19: Brazilian trial for drug touted by Trump halted after 11 patients die when put on high doses recommendations use low doses ( show improvements on patients) and monitor patients that have heart problems avoid high doses! <~~~~ edit title for you !

https://nationalpost.com/news/world/covid-19-brazil-trial-for-drug-chloroquine-touted-by-trump-stopped-after-11-patients-die

COVID-19: Brazilian trial for drug touted by Trump halted after 11 patients die on high dose
The New York Times reports that a number of patients on chloroquine in a clinical trial developed what proved to be fatal heart arrhythmia

National Post StaffNational Post Staff
More from National Post Staff
Published on: April 14, 2020 | Last Updated: April 14, 2020 4:38 PM EDT

A possible treatment for COVID-19, heavily touted by U.S. President Donald Trump in recent weeks, has been withdrawn from high-dose use in a Brazilian trial because it was feared to be having adverse effects on patients’ hearts.

Chloroquine, normally a drug used to treat malaria, has inspired hope in some medical circles amid reports that it can help to offset the symptoms of the deadly virus. But the New York Times reports that a recent clinical trial saw patients develop irregular heartbeats, a number of whom developed heart arrhythmias and later died.

The similar drugs chloroquine and hydroxychloroquine have been pushed by Trump as a possible partial solution to the pandemic in the U.S., where they are sold under brand names like Nivaquine and Plaquenil. The Times reports that the U.S. Food and Drug Administration has granted emergency approval for the use of both drugs at U.S. hospitals, and U.S. companies have begun producing them in greater numbers. Trump has been vociferous on the drugs’ potential benefits, but among those to contradict his views are his own top expert Anthony Fauci, who has provided regular updates to Americans on the crisis. During one recent daily White House coronavirus briefing, Trump stepped in and prevented Fauci from answering a question about hydroxychloroquine.

Experts say that in reality there is not much to back up theories that chloroquine and hydroxychloroquine are effective against COVID-19. Cholroquine was first touted as a treatment during the MERS outbreak of 2012, Science Alert reports, but it wasn’t pursued because it wasn’t proving to be effective.


The Brazil study was undertaken with 81 patients at a hospital in Manaus, in Amazonas state. As well as chloroquine, patients were also given azithromycin, an antibiotic also being used in the U.S., often paired with chloroquine. However, higher dose use of chloroquine (600 milligrams as opposed to 450 milligrams) was stopped after just six days, after 11 of patients who were given the greater dose died.

The news will likely fuel further doubts about the efficacy of the drugs; in recent days, statements advocating caution around their use have not been hard to find.

Robert A. Harrington of the American Heart Association, said in a recent statement on azithromycin and hydroxychloroquine:

“The urgency of COVID-19 must not diminish the scientific rigor with which we approach COVID-19 treatment. While these medications may work against COVID-19 individually or in combination, we recommend caution with these medications for patients with existing cardiovascular disease.”

Dr. David Juurlink, head of the division of clinical pharmacology at the University of Toronto, told the New York Times of the Brazil study:

“To me, this study conveys one useful piece of information, which is that chloroquine causes a dose-dependent increase in an abnormality in the ECG (electrocardiogram) that could predispose people to sudden cardiac death.”

At least one province in China, Guangdong, had recommended similarly high doses of chloroquine to treat patients, the Times reports, and Dr. Marcus Lacerda, who worked on the Brazil study, told the Times that the new work showed that “the high dosage that the Chinese were using is very toxic and kills more patients.”

“That is the reason this arm of the study was halted early,” he said.

One New York area hospital told the Times it does not plan to stop using the hydroxychloroquine-azithromycin combination in lower doses, on patients who aren’t severely ill.

On April 7, the U.S. Centers for Disease Control and Prevention removed from its website highly unusual guidance informing doctors on how to prescribe hydroxychloroquine and chloroquine.

The move came three days after Reuters reported that the CDC published key dosing information involving the two antimalarial drugs based on unattributed anecdotes rather than peer-reviewed science.

PS: For your info

https://www.thehealthsite.com/diseases-conditions/an-overdose-of-vitamin-e-can-kill-d915-327055/
Home / Diseases & Conditions / An overdose of Vitamin E can kill!
An overdose of Vitamin E can kill!
Internal bleeding is a real risk and so are the rest of these health problems due to excess vitamin E.

PPS. Newspaper has misleading headline or incomplete info on Title of articles ! Too much of anything can kill you! The they need to find the correct low doses and obviously now you need to not give high doses to people have heart problems! Bottom line high doses kill you!
Then use low doses!

 

[lenny2]

With corona though mutations are much less prevelant/likely as opposed to influenza. This is not the first or last type of corona virus we have seen and from our findings in previous corona viruses we know thankfully they mutate less.

This present novel corono is unlike previous ones. They didn't shutdown the world while having a high rate of infection & deaths. A vaccine may never come & there is still much that isn't known about COVID-19.

"Since the mid 60's the human coronaviruses (HCoV), represented by HCoV-OC43 and HCoV-229E, were generally considered relatively harmless viruses. This status changed dramatically with the emergence of SARS-CoV in 2002/2003."

https://www.ncbi.nlm.nih.gov/pubmed/17346212

"There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections."

 

[Ben19]

This present novel corono is unlike previous ones. They didn't shutdown the world while having a high rate of infection & deaths. A vaccine may never come & there is still much that isn't known about COVID-19.

"There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections."

I agree with you there. There are many challenges with this new virus that make it extremely challenging and warranting of the current drastic world wide efforts. One of the main ones being that its novel with no understanding of what the immunity will be like.

My point in that sentence is that while mutations may be yet another challenge amonst the many others posed by this virus, historically these types of viruses mutate less. Of course we dont know that for sure and that does not mean we should downplay it. The fact that the virus surface is covered by unique glycans (sugars) makes it even a harder target for vaccines than what we are used to.

 

[danmand]

Scientists Discover Alarming Coronavirus Mutation That Could Render Vaccine Useless

Thu, 04/16/2020 - 09:45

The prospect that SARS-CoV-2, the "novel" coronavirus responsible for causing the illness COVID-19, might be mutating and evolving as it spreads across the globe has been such a terrifying prospect for the scientific community, that medical experts like Dr. Anthony Fauci seem to avoid even engaging on the topic.



Asked about the possibility of viral mutation during one of the White House's inaugural task force press briefings, Dr. Fauci assured the public that scientists have found "no evidence" of any concerning mutations, though the prospect that a mutated version of the virus might return during next year's flu season has kept some virologists up at night with nightmares about needing to start the vaccine clock from zero.

The problem is that vaccines often aren't as effective against viruses that mutate, like the flu does every season (that's why you need to keep getting that flu shot year after year). And now, a new scientific paper that - like most of the coronavirus research being cited in the press - has yet to be peer reviewed claims to have identified a mutation in a sample of the virus collected in India that could create serious problems for researchers working on a vaccine.


Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective approaches to contain the 21 pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome sequences, we provided direct genetic evidence that 22 SARS-CoV-2 has a much lower mutation rate than SARS. Minimum Evolution phylogeny analysis revealed the putative original status of SARS-CoV-2 and the early-stage spread history. The discrepant phylogenies for the spike protein and it receptor binding domain proved a previously reported structural rearrangement prior to the emergence of SARS-CoV-2. Despite that, we found the spike glycoprotein of SARS-CoV-2 is particularly more conserved, we identified a mutation that leads to weaker receptor binding capability, which concerns a SARS-CoV-2 sample collected on 27th January 2020 from India. This represents the first report of a significant SARS-CoV-2 mutant, and raises the alarm that the ongoing vaccine Development may become futile in future epidemic if more mutations were identified.

The ominous discovery underscores how the virus's destructive potential will likely be tied to the vagaries of viral evolution.

Fortunately, the team appeared to confirm an earlier finding by a team of researchers in Italy that the virus "has a much lower mutation rate and genetic diversity" than SARS, which means that a vaccine will likely be able to treat wide swaths of people before becoming ineffective as the virus changes and evolves.


However, this new finding shows that it's not just the speed of the mutation that matters, but the specific nature of the mutations, when scientists are developing a vaccine.

Experts say that a vaccine could take up to 2 years to develop, and some city officials have warned that life likely won't return completely back to normal until a vaccine is ready for mass production. But a mutation could throw a wrench in this process, transforming the process of developing a workable vaccine into a "cat and mouse" game - or at the very least lengthen the time it takes for the initial vaccine to be developed.

 

[mandrill]

Scientists Discover Alarming Coronavirus Mutation That Could Render Vaccine Useless

Thu, 04/16/2020 - 09:45

The prospect that SARS-CoV-2, the "novel" coronavirus responsible for causing the illness COVID-19, might be mutating and evolving as it spreads across the globe has been such a terrifying prospect for the scientific community, that medical experts like Dr. Anthony Fauci seem to avoid even engaging on the topic.



Asked about the possibility of viral mutation during one of the White House's inaugural task force press briefings, Dr. Fauci assured the public that scientists have found "no evidence" of any concerning mutations, though the prospect that a mutated version of the virus might return during next year's flu season has kept some virologists up at night with nightmares about needing to start the vaccine clock from zero.

The problem is that vaccines often aren't as effective against viruses that mutate, like the flu does every season (that's why you need to keep getting that flu shot year after year). And now, a new scientific paper that - like most of the coronavirus research being cited in the press - has yet to be peer reviewed claims to have identified a mutation in a sample of the virus collected in India that could create serious problems for researchers working on a vaccine.


Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective approaches to contain the 21 pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome sequences, we provided direct genetic evidence that 22 SARS-CoV-2 has a much lower mutation rate than SARS. Minimum Evolution phylogeny analysis revealed the putative original status of SARS-CoV-2 and the early-stage spread history. The discrepant phylogenies for the spike protein and it receptor binding domain proved a previously reported structural rearrangement prior to the emergence of SARS-CoV-2. Despite that, we found the spike glycoprotein of SARS-CoV-2 is particularly more conserved, we identified a mutation that leads to weaker receptor binding capability, which concerns a SARS-CoV-2 sample collected on 27th January 2020 from India. This represents the first report of a significant SARS-CoV-2 mutant, and raises the alarm that the ongoing vaccine Development may become futile in future epidemic if more mutations were identified.

The ominous discovery underscores how the virus's destructive potential will likely be tied to the vagaries of viral evolution.

Fortunately, the team appeared to confirm an earlier finding by a team of researchers in Italy that the virus "has a much lower mutation rate and genetic diversity" than SARS, which means that a vaccine will likely be able to treat wide swaths of people before becoming ineffective as the virus changes and evolves.


However, this new finding shows that it's not just the speed of the mutation that matters, but the specific nature of the mutations, when scientists are developing a vaccine.

Experts say that a vaccine could take up to 2 years to develop, and some city officials have warned that life likely won't return completely back to normal until a vaccine is ready for mass production. But a mutation could throw a wrench in this process, transforming the process of developing a workable vaccine into a "cat and mouse" game - or at the very least lengthen the time it takes for the initial vaccine to be developed.

The virus is structurally simpler than most other viruses and therefore, there is less to chemically mutate, rendering the mutation rate lower than more complex viruses.

So mutation remains a concern, but less so.

 

[WyattEarp]

Scientists Discover Alarming Coronavirus Mutation That Could Render Vaccine Useless

Thu, 04/16/2020 - 09:45

The prospect that SARS-CoV-2, the "novel" coronavirus responsible for causing the illness COVID-19, might be mutating and evolving as it spreads across the globe has been such a terrifying prospect for the scientific community............

You should reference the source or post the hyperlink for an article. Thanks.

 

[danmand]

You should reference the source or post the hyperlink for an article. Thanks.

Google is your friend

https://www.sciencetimes.com/articl...tation-india-threaten-vaccine-development.htm

 

[lenny2]

"Even moderately effective therapies or combinations could dramatically reduce the crushing demand on hospitals and intensive care units, changing the nature of the risk the new pathogen represents to populations and healthcare systems."

https://www.reuters.com/article/us-...cs-that-may-conquer-coronavirus-idUSKBN21Z2HP

 

[wigglee]

Do I need a prescription?

What do I need to tell my doctor if I want to get some?

just find a doctor who wears a maga hat

 

[sp free]

The virus mutation making it more difficult to bind to receptors is bad?

Seems to me that would be pretty good.

 

[lenny2]

Dr. Vladimir Zelenko, a board-certified family practitioner in New York, said in a video interview that a cocktail of Hydroxychloroquine, Zinc Sulfate and Azithromycin are showing phenomenon results with 900 coronavirus patients treated.

Dr. Anthony Cardillo, an ER specialist and the CEO of Mend Urgent Care, has been prescribing the zinc and hydroxychloroquine combination on patients experiencing severe symptoms associated with COVID-19. Cardillo stated:

There quite a history of SUPPRESSING THE POTENTIAL BENEFITS of Hydroxychloroquine. There’s no money to be made from a 60-year-old drug with an expired patent!

"The medical industry, including complicit doctors who take the hippocratic oath, mind you, are all about prescribing the new big money maker. Sometimes the answer is something old and cheap."

https://www.covers.com/forum/politics-87/covid-19-good-and-bad-103433058/18

 

[Frankfooter]

No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial

 

[sp free]

Media pushing anti hydroxychloroquine narrative in spite of clinical success. Drug is out of patent, cheap and normally easy to acquire.

Media pushing positive spin on Remdisivir. Drug is new, and stands to make a lot of people a lot of money.

Open your eyes.

 

[danmand]

Media pushing anti hydroxychloroquine narrative in spite of clinical success. Drug is out of patent, cheap and normally easy to acquire.

Media pushing positive spin on Remdisivir. Drug is new, and stands to make a lot of people a lot of money.

Open your eyes.

Objectively, I think you are wrong about pig pharma. I am not saying that they are angels and not out to maximize profits, but there are a lot of drugs many people take regularly, that are cheap.
I take Metformin, which cost 10 cents a tablet, and that is the most widely prescribed drug for Type II diabetes. Old fashioned insulin is also very cheap.

If hydroxychloroquine works, the cost will not be a reason not to use it.

 

[Ben19]

Media pushing anti hydroxychloroquine narrative in spite of clinical success. Drug is out of patent, cheap and normally easy to acquire.

Media pushing positive spin on Remdisivir. Drug is new, and stands to make a lot of people a lot of money.

Open your eyes.

What clinical success? A few trials looking at viral load when not meeting randomization criteria with post hoc retrospective analysis cannot be classified as "success". It may very well be a success but it is too early to tell and there are results being published showing no benefit when compared to placebo on clinical outcomes. I am patiently awaiting more results of this drug to come out to hopefully be in favour but I would have my bets on the MANY other drugs that have shown better results and more promise without this much attention from the public. Ironically all this attention is from the media which the same group that is often in favour of this drug claims to be fake. You also realize that at BEST this may reduce the load of the disease slightly, and may not even change mortality or ICU admission rates.

Also this notion that all the healthcare field are in this wide spread conspiracy to make the drug companies money is in my opinion ignorant. I appreciate the critical thinking and the scrutinity over the drug companies who deserve it, but at the end of the day physicians are the ones prescribing these drugs and they are also part of society and have loved ones and themselves to worry about. An entire field of physicians and researchers are not gonna subscribe to this wide spread of a conspiracy to make some drug company a drug. You can argue that the drug companies have them fooled via false advertisement and penetration into key groups within the field and that is a fair argument but I would argue against it on a topic that is this wide spread. Everyone is going to have their critical thinking hat on and analyze every bit of data that comes out. If anything we are seeing some crooked docs take advantage of this. There was a MD in san fran selling hydroxycholorquine kits for 4grand to his patients and advertising it as a cure. They have charged him but his lawyer is arguing that this doctor meerly took the advice of the executive branch of the government....

 

[sp free]

So much fail in one post. I won’t waste the energy required to rebuke every single point because it’s not worth the effort.

If you end up in the hospital with the Wuhan virus...don’t take hydroxychloroquine. Easy.

 

[danmand]

So much fail in one post. I won’t waste the energy required to rebuke every single point because it’s not worth the effort.

If you end up in the hospital with the Wuhan virus...don’t take hydroxychloroquine. Easy.

You would be well advised to read and learn something from Ben19's posts.

 

[mandrill]

Also this notion that all the healthcare field are in this wide spread conspiracy to make the drug companies money is in my opinion ignorant. I appreciate the critical thinking and the scrutinity over the drug companies who deserve it, but at the end of the day physicians are the ones prescribing these drugs and they are also part of society and have loved ones and themselves to worry about. An entire field of physicians and researchers are not gonna subscribe to this wide spread of a conspiracy to make some drug company a drug. You can argue that the drug companies have them fooled via false advertisement and penetration into key groups within the field and that is a fair argument but I would argue against it on a topic that is this wide spread. Everyone is going to have their critical thinking hat on and analyze every bit of data that comes out. If anything we are seeing some crooked docs take advantage of this. There was a MD in san fran selling hydroxycholorquine kits for 4grand to his patients and advertising it as a cure. They have charged him but his lawyer is arguing that this doctor merely took the advice of the executive branch of the government....

That's not a recognized defence in this case, btw. The lawyer is BS-ing to get on TV, probably as crooked as his doctor-client.

 

[sp free]

You would be well advised to read and learn something from Ben19's posts.

Like what?

 

[lurkerdick]

Dr Trump also suggested covid19 will be over by Easter