Getting hydroxychloroquine
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Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Abstract
Background: Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion: Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
pubmed.ncbi.nlm.nih.gov
Abstract
Background: Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion: Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread - PubMed
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein...
pubmed.ncbi.nlm.nih.gov
There is evidence and I've heard and believe it to be true that the drug Hydroxychloroquine does magic on people for the greater good of mankind and the safety of their communities, it not only protects one against the Coronavirus, but also protects others from ones sheer ignorance spouting on the subject when specifically combined with injecting oneself with disinfectant
Disclaimer: To experience the full scope of efficacy from Hydroxychloroquine it must be combined with Sodium Hypochlorite
Dosage: Hydroxychloroquine: 4/400MG oral intake daily
Sodium Hypochlorite AKA Household bleach: 1 Quart oral or rectal intake once
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More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by AAPS
aapsonline.org
More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by AAPS
This week the Association of American Physicians & Surgeons submitted additional evidence to a federal court for why interference with hydroxychloroquine (HCQ) should end by the Food & Drug…
aapsonline.org
You should try it sometime.There is evidence and I've heard and believe it to be true that the drug Hydroxychloroquine does magic on people for the greater good of mankind and the safety of their communities, it not only protects one against the Coronavirus, but also protects others from ones sheer ignorance spouting on the subject when specifically combined with injecting oneself with disinfectant
Disclaimer: To experience the full scope of efficacy from Hydroxychloroquine it must be combined with Sodium Hypochlorite
Dosage: Hydroxychloroquine: 4/400MG oral intake daily
Sodium Hypochlorite AKA Household bleach: 1 Quart oral or rectal intake once
Make sure you get the extra large size bottle too, I have a feeling small bottles wont fit in you
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This is a study from 2005. It refers ONLY to SARS 2, another coronavirus, NOT COVID 19. Nice try.Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Abstract
Background: Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion: Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread - PubMed
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein...
Nice try from a heavily biased group of 'physicians'. who are using their medical status to promote right-wing ideology.More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by AAPS
More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by AAPS
This week the Association of American Physicians & Surgeons submitted additional evidence to a federal court for why interference with hydroxychloroquine (HCQ) should end by the Food & Drug…
Association of American Physicians and Surgeons - Wikipedia
en.wikipedia.org
The Association of American Physicians and Surgeons (AAPS) is a conservative non-profit association founded in 1944. The group was reported to have about 5,000 members in 2014. The association has promoted a range of scientifically discredited hypotheses, including the belief that HIV does not cause AIDS, that being gay reduces life expectancy, that there is a link between abortion and breast cancer, and that there is a causal relationship between vaccines and autism. It is opposed to the Affordable Care Act and other forms of universal health insurance.
Journal of American Physicians and Surgeons
Journal of American Physicians and Surgeons
| Publication details | |
|---|---|
| Standard abbreviations | |
| Indexing | |
| Discipline | Medicine |
| Language | English |
| Former name(s) | Medical Sentinel |
| History | 1996–present |
| Publisher | Association of American Physicians and Surgeon |
| Frequency | Quarterly |
| ISO 4 | J. Am. Physicians Surg. |
| ISSN | 1543-4826 |
The association's Journal of American Physicians and Surgeons (JPandS), from 1996 to 2003 named the Medical Sentinel, is not listed in academic literature databases such as MEDLINE/PubMed or the Web of Science. The quality and scientific validity of articles published in the journal have been criticized by medical experts, and some of the viewpoints advocated by AAPS are rejected by mainstream scientists and other medical groups.[24] The U.S. National Library of Medicine declined repeated requests from AAPS to index the journal, citing unspecified concerns.[24]
As of September 2016, JPandS was listed on Beall's list of potential or probable predatory open-access journals.[25] Quackwatch lists JPandS as an untrustworthy, non-recommended periodical.[26] An editorial in Chemical & Engineering News described the journal as a "purveyor of utter nonsense."[27] Investigative journalist Brian Deer wrote that the journal is the "house magazine of a right-wing American fringe group [AAPS]" and "is barely credible as an independent forum."[28] Writing in The Guardian, science columnist Ben Goldacre described the journal as the "in-house magazine of a rightwing US pressure group well known for polemics on homosexuality, abortion and vaccines."[29]
Publishing of non-mainstream or scientifically discredited claims
Articles and commentaries published in the journal have argued a number of non-mainstream or scientifically discredited claims,[24] including:
- that human activity has not contributed to climate change, and that global warming will be beneficial and thus is not a cause for concern.[30][31]
- that HIV does not cause AIDS.[32]
- that the "gay male lifestyle" shortens life expectancy by 20 years.[33]
- that there is a link between abortion and the risk of breast cancer.[3]
- that there are possible links between autism and vaccinations.[3]
- that government efforts to encourage smoking cessation and emphasize the addictiveness of nicotine are misguided.[34]
A series of articles by anti-abortion authors published in the journal argued for a link between abortion and breast cancer.[35][36] Such a link has been rejected by the scientific community, including the U.S. National Cancer Institute,[37] the American Cancer Society,[38] and the World Health Organization,[39] among other major medical bodies.[40]
A 2003 paper published in the journal, claiming that vaccination was harmful, was criticized for poor methodology, lack of scientific rigor, and outright errors by the World Health Organization[41] and the American Academy of Pediatrics.[42] A National Public Radio piece mentioned inaccurate information published in the Journal and said: "The journal itself is not considered a leading publication, as it's put out by an advocacy group that opposes most government involvement in medical care."[43]
The journal has also published articles advocating politically and socially conservative policy positions, including:
- that the Food and Drug Administration and Centers for Medicare and Medicaid Services are unconstitutional;[44]
- that "humanists" have conspired to replace the "creation religion of Jehovah" with evolution;[45]
- that "anchor babies" are valuable to undocumented immigrants, particularly if the babies are disabled.[24]
The organization published on its website an article claiming that Obama hypnotized audiences with his speeches, using "extra slow speech, rhythm, tonalities, vagueness, visual imagery, metaphor, and raising of emotion." The "O" in Obama's logo was compared to a crystal ball used as a "point of visual fixation".[34]
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Regardless of what you or I think it is in front of the courts and professionals now to decide and not you, me or another speculation.Nice try from a heavily biased group of 'physicians'. who are using their medical status to promote right-wing ideology.
Association of American Physicians and Surgeons - Wikipedia
The Association of American Physicians and Surgeons (AAPS) is a conservative non-profit association founded in 1944. The group was reported to have about 5,000 members in 2014. The association has promoted a range of scientifically discredited hypotheses, including the belief that HIV does not cause AIDS, that being gay reduces life expectancy, that there is a link between abortion and breast cancer, and that there is a causal relationship between vaccines and autism. It is opposed to the Affordable Care Act and other forms of universal health insurance.
Publishing of non-mainstream or scientifically discredited claims
Articles and commentaries published in the journal have argued a number of non-mainstream or scientifically discredited claims,[24] including:
- that human activity has not contributed to climate change, and that global warming will be beneficial and thus is not a cause for concern.[30][31]
- that HIV does not cause AIDS.[32]
- that the "gay male lifestyle" shortens life expectancy by 20 years.[33]
- that there is a link between abortion and the risk of breast cancer.[3]
- that there are possible links between autism and vaccinations.[3]
- that government efforts to encourage smoking cessation and emphasize the addictiveness of nicotine are misguided.[34]
A series of articles by anti-abortion authors published in the journal argued for a link between abortion and breast cancer.[35][36] Such a link has been rejected by the scientific community, including the U.S. National Cancer Institute,[37] the American Cancer Society,[38] and the World Health Organization,[39] among other major medical bodies.[40]
A 2003 paper published in the journal, claiming that vaccination was harmful, was criticized for poor methodology, lack of scientific rigor, and outright errors by the World Health Organization[41] and the American Academy of Pediatrics.[42] A National Public Radio piece mentioned inaccurate information published in the Journal and said: "The journal itself is not considered a leading publication, as it's put out by an advocacy group that opposes most government involvement in medical care."[43]
The journal has also published articles advocating politically and socially conservative policy positions, including:
- that the Food and Drug Administration and Centers for Medicare and Medicaid Services are unconstitutional;[44]
- that "humanists" have conspired to replace the "creation religion of Jehovah" with evolution;[45]
- that "anchor babies" are valuable to undocumented immigrants, particularly if the babies are disabled.[24]
The organization published on its website an article claiming that Obama hypnotized audiences with his speeches, using "extra slow speech, rhythm, tonalities, vagueness, visual imagery, metaphor, and raising of emotion." The "O" in Obama's logo was compared to a crystal ball used as a "point of visual fixation".[34]
“This week the Association of American Physicians & Surgeons submitted additional evidence to a federal court for why interference with hydroxychloroquine (HCQ) should end by the Food & Drug Administration (FDA) and the Department of Health & Human Services (HHS), in AAPS v. FDA, No. 1:20-cv-00493-RJJ-SJB (W.D. Mich.).”
More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by AAPS
This week the Association of American Physicians & Surgeons submitted additional evidence to a federal court for why interference with hydroxychloroquine (HCQ) should end by the Food & Drug…
aapsonline.org
I trust a reliable and unbiased physicial over a partisan 'judge' with my health.
and what unbiased is that based on LOl, based on your biases and world views?
I trust my doctor and the medical profession period. If I need a second opinion I can easily do this as well if I need to or feel like like it however I have never to date felt like I couldn’t trust my doctors professional opinion.
You failed to look at the reliability of the source that you quoted, a source that is rife with conspiracy theories and unfounded claims. End of story. I am done with arguing with you.
BREAKING: Ohio Reverses Ban On Hydroxychloroquine As Coronavirus Treatment - The National Pulse
Ohio health officials have reversed a rule blocking doctors’ ability to prescribe hydroxychloroquine, which many including President Trump allege may be a treatment for coronavirus. According to the Associated Press: The Ohio pharmacy board has rescinded a rule prohibiting the prescription of a...
thenationalpulse.com
Wow, you can read.
The point canada-man (I think) was making is that its been shown to work on other coronaviruses as well.
So its quite plausible that if it works on one in the coronavirus family, it will work on another as well.
Thats a US government study btw, they are very often quite accurate
That's one of the main reason it and other antivirals were looked at. There is some overlap in function and plenty of reason to think one might be helpful against another virus than the one it is known for.
In the end, the evidence for HCQ isn't there. It may be helpful very early, maybe as prophylactic, but not so much that it is an obvious choice. So people moved on to other things except for the weird conspiracy theorists and a few people who want to play out then early treatment threads because nothing else has shown to be much better.
The argument against is that the run on the drug has put people using it for lupus and the like in trouble due to shortage. In any other year this wouldn't be controversial, but Trump decided to make it a shibboleth and here we are.
Now do Remdesivir.
Patently useless, the WHO yanked the study off their site when Gilead shares started to tank.
Quite an “error”.
You legitimately have to be retarded to believe that a drug that everyone says works, but nobody can get rich off, isn’t being unjustly buried by the same people that stand to make a killing off of Remdesivir.
SARS 1 you mean.
Factor in that Covid-19 is lab altered SARS 1, and you’ll understand why they tried it in the first place, and why it works.
The WHO stopped the trials for the drug when large scale trials and randomized trials proved the efficacy of the drug Hydroxychloroquine to be no different than placebo.
Again the "Stable Genius" crowd need to read the larger scale and randomized studies instead of looney tune Alt Right websites to understand what this means but that would require rational as well as some common knowledge which is not so common.
So we should listen to media, politicians and bureaucrats instead of doctors?
Not me.
Not me.
