NADs and health

[buckstarbuck]

So there’s a lot of hype about taking NADs and I was wondering if anyone had any experience with this product. Any doctors in the house?
I am in my 50s and looking to optimize my fitness/recovery.

Here are the main deets on NADs, copied from google AI:

“NAD+ supplementation shows promise in animal models for extending lifespan and reducing signs of aging, with early human trials demonstrating potential benefits like improved exercise performance, insulin sensitivity, and anti-inflammatory effects. However, more robust clinical trials with larger sample sizes are needed to confirm these findings and determine the optimal dosages and long-term effects in humans.”

Have you taken NADs? Where’d you get them? I ordered some from ZOONE but I now see that it’s coming from China. The shipping updates are not even in English. Don’t know if I should take them. I’ll probably chuck it if it arrives at all.

And if you have any perspective on anything else interesting on the subject of fitness/anti-aging…TRT, drinking the blood of virgins, whatever, please feel free to chime in.

 

[ogibowt]

I for one miss out on alot because im illiterate to modern jargon...whenever i read something that has letters to substitute for words im clueless as to what is being said
Bottom Line...what the heck does NADS refer to...

 

[Shaquille Oatmeal]

I asked ChatGPT for the short version of their efficacy and also about what they are.
In short it looks unconvincing, so I wouldn't really bother.

NAD supplementation refers to taking compounds that boost levels of NAD⁺ (nicotinamide adenine dinucleotide) in the body. NAD⁺ is a vital coenzyme found in all living cells, essential for:

• Energy production (in mitochondria via the electron transport chain)
• DNA repair
• Cell signaling
• Gene expression regulation via sirtuins

Types of NAD⁺ Supplements
NAD⁺ itself isn’t well absorbed when taken orally, so people use precursors:

Compound	Full Name	Notes
NR	Nicotinamide riboside	Well studied, available in supplements like Tru Niagen
NMN	Nicotinamide mononucleotide	Promoted by researchers like David Sinclair
Nicotinamide	A form of vitamin B3	Cheaper, but less efficient for NAD⁺ synthesis
Niacin	Also vitamin B3	Can cause flushing at higher doses

Here's a clear and compact table showing the most common NAD⁺ supplements, their claimed benefits, and whether each is proven, unproven, or partially supported by science:
NAD⁺ Supplementation: Evidence Table

Supplement	Claimed Benefit	Evidence Status	Notes
NR (Nicotinamide Riboside)	Increases NAD⁺ in blood	Proven	Multiple human trials confirm increase
	Improves mitochondrial function	Partially Supported	Evidence in animals; human results mixed
	Anti-aging / longevity	Unproven	No human data showing longer life
	Cognitive benefits	Partially Supported	Some early evidence in older adults
	Improves metabolic health	Partially Supported	Mild improvements in insulin sensitivity in some studies
	Prevents age-related diseases	Unproven	No clinical trials proving prevention or reversal

Supplement	Claimed Benefit	Evidence Status	Notes
NMN (Nicotinamide Mononucleotide)	Boosts NAD⁺ levels	Proven	Human trials show increased NAD⁺, esp. in blood
	Increases endurance/energy	Partially Supported	Seen in mice; early human studies promising
	Anti-aging effects	Unproven	Longevity claims only proven in mice
	Improves cardiovascular function	Partially Supported	Small-scale studies show improved blood flow in older adults
	Cognitive improvement	Unproven	No strong clinical data yet

Supplement	Claimed Benefit	Evidence Status	Notes
Niacin (Vitamin B3)	Boosts NAD⁺ (indirectly)	Proven	But less targeted; can cause flushing
	Lowers cholesterol	Proven	Approved treatment for dyslipidemia
	Anti-aging or energy boost	Unproven	Not effective for these at standard doses

Supplement	Claimed Benefit	Evidence Status	Notes
Nicotinamide (NAM)	Supports NAD⁺ synthesis	Proven	A core B3 form; widely used in multivitamins
	Enhances DNA repair	Partially Supported	Shown in vitro and animal models
	Anti-aging/longevity	Unproven	No clinical proof in humans

Summary by Benefit

Benefit	Evidence Summary
Boosts NAD⁺ levels	Proven (NR, NMN, Niacin, NAM)
Improves energy/metabolism	Promising but limited human data
Anti-aging/lifespan extension	Unproven in humans
Prevents/reverses age-related disease	Unproven
Cognitive/neurological benefits	Early signals, more research needed
Long-term safety	Unknown — short-term use seems safe

 

[buckstarbuck]

I for one miss out on alot because im illiterate to modern jargon...whenever i read something that has letters to substitute for words im clueless as to what is being said
Bottom Line...what the heck does NADS refer to...

Nicotinamide adenine dinucleotide (NAD) is a compound found naturally in your body's cells. It's also available in supplement form. NAD, sometimes referred to by its other formats, NAD+ and NADH, is a key player in various cell functions, including helping to regulate your body's metabolic and inflammatory responses

 

[Robert Mugabe]

I for one miss out on alot because im illiterate to modern jargon...whenever i read something that has letters to substitute for words im clueless as to what is being said
Bottom Line...what the heck does NADS refer to...

The nads - Idioms by The Free Dictionary

 

[buckstarbuck]

The nads - Idioms by The Free Dictionary

So helpful.

 

[thumper18474]

And here I thought he was talking about testicular issues!

 

[ogibowt]

The nads - Idioms by The Free Dictionary

lol...short form for gonads.....as for Nads...gimme a break....just eat right, exercise, dont use alcohol excessively...and make sure that your parents had/have good genes and live/lived well into their 80,s

 

[buckstarbuck]

lol...short form for gonads.....as for Nads...gimme a break....just eat right, exercise, dont use alcohol excessively...and make sure that your parents had/have good genes and live/lived well into their 80,s

All those are and valid points. Just looking to improve recovery, etc…ie the purported benefits of NADs.

(NAD, in this case, is not an abbreviation for gonad)

 

[Mandala]

Seems like the latest celeb thing

My research indicates no confirmed negative health effects but ask MD if you are on drugs

You can inject or use pills. No MD is involved as no prescription required

Injection is around $70

According to the nurse I saw she says everyone seems to get more energy and mental clarity but that could be placebo and besides she is selling the stuff along with botox

I think I will spend a few hundred for a few injections to see WTF happens so stay tuned. It seems toi me if the energy boost and mental clarity stuff is not undeniable then waste of money as longevity claims are ungrounded based on mouse study so forget about that

I am skeptical but a few hundred to me means nothing
Nice to have $

 

[buckstarbuck]

Seems like the latest celeb thing

My research indicates no confirmed negative health effects but ask MD if you are on drugs

You can inject or use pills. No MD is involved as no prescription required

Injection is around $70

According to the nurse I saw she says everyone seems to get more energy and mental clarity but that could be placebo and besides she is selling the stuff along with botox

I think I will spend a few hundred for a few injections to see WTF happens so stay tuned. It seems toi me if the energy boost and mental clarity stuff is not undeniable then waste of money as longevity claims are ungrounded based on mouse study so forget about that

I am skeptical but a few hundred to me means nothing
Nice to have $

Hey where did you go for this?

 

[Mandala]

Hey where did you go for this?

All over. Google is your friend
Places thst deal with beauty like botox and stuff

 

[Mandala]

Longevity is a lot of noise

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