Larry David yelling like a lunatic as Steinbrenner, he easily was the most insane character on the show besides Crazy Joe Davola
George as a marine biologist, "The sea was angry that day".
I was in the Pool! I was in the Pool!
Julia Dreyfus did get the lead on a show and it does pretty good. (I've never watched it but has decent ratings) It's called Veep.