Similar to the Sanofi-GSK Covid 19Vaccine
Novavax COVID-19 vaccine - Wikipedia
What is Novavax and what do moths have to do with producing the non-mRNA vaccine? - CNA (channelnewsasia.com)
What is the Novavax vaccine and how is it different from other vaccines being used now? Here's what we know so far:
PROTEIN-BASED VACCINE
Novavax calls its approach recombinant nanoparticle vaccine technology, it has also been called a protein sub-unit vaccine.
The technology has been in use for two decades to make vaccines, including for whooping cough and shingles.
According to a CNN report, Novavax clones a modified version of the gene for the COVID-19 virus spike protein into a baculovirus that infects insects.
Scientists then infect moth cells with that virus, spurring them to produce the coronavirus spike protein. These virus-like nanoparticles are harvested to make the vaccine.
Sinovac uses the whole, deactivated virus, while vector vaccines, like AstraZeneca, use an adenovirus to carry genetic instructions for the human body to make the spike protein. mRNA vaccines like Pfizer-BioNTech and Moderna use pieces of genetic material called messenger RNA to instruct cells to make a piece of the coronavirus spike protein.
All of them have the same purpose - to stimulate the body to produce an immune response to the virus without actually causing illness.
The main difference between Novavax and the mRNA or vector vaccines is that it is made with lab-grown copies of the COVID-19 spike protein, whereas vector and mRNA vaccines include genetic instructions for the body to make its own spike protein.
Novavax requires two doses given 21 days apart and the vaccine is stable at 2 to 8 deg Celsius, which are standard refrigerator temperatures. This means that it will be easier to store and transport for low and middle-income countries.
HIGH EFFICACY
The Novavax jab is about 90 per cent effective against COVID-19 across a variety of variants of the virus.
In Phase 3 trials in the UK earlier this year, it was 89.3 per cent effective at preventing COVID-19 and around 86 per cent effective at protecting against the Alpha variant from the UK.
It was 95.6 per cent effective against the original COVID-19 strain.
In a late-stage study in the United States and Mexico, it was more than 93 per cent effective against the predominant virus variants of concern.
It has shown far less efficacy against the Beta variant at about 55 per cent among HIV-negative people in a trial in South Africa.
However, it is 100 per cent effective at preventing moderate and severe disease, similar to other approved vaccines.
FEWER SIDE EFFECTS
Novavax has said that the vaccine was generally well-tolerated among participants.
Side effects included headache, fatigue and muscle pain and were generally mild. A small number of participants experienced side effects described as severe.
Data showed that about 40 per cent of people who received Novavax reported fatigue after the second dose, as compared with 65 per cent for Moderna and more than 55 per cent for Pfizer, the Atlantic said.
VACCINE PRODUCTION
According to news reports, the vaccine has taken longer to complete trials and ramp up production because the US company has faced operational issues.
It is small compared to the pharmaceutical giants that have had their vaccines approved so far.
However, it has now got the funding and manufacturing partners to ramp up production.
South Korea's SK Bioscience was reported to begin manufacturing Novavax COVID-19 vaccines in June and the Serum Institute of India is also supposed to make millions of doses of the Novavax shot, known there as Covovax, for the WHO-backed COVAX scheme.
What is Novavax and what do moths have to do with producing the non-mRNA vaccine? - CNA (channelnewsasia.com)
Novavax says COVID-19 vaccine highly effective in trials | CBC News
Mostly mild side effects
Side effects were mostly mild — tenderness and pain at the injection site. There were no reports of unusual blood clots or heart problems, Erck said.
Novavax reported the results in a press release and plans to publish in a medical journal, where it will be vetted by independent experts. The Maryland-based company previously released findings from smaller studies in Britain and South Africa.
COVID-19 vaccines train the body to recognize the coronavirus, especially the spike protein that coats it, and get ready to fight the virus off. The Novavax vaccine is made with lab-grown copies of that protein. That's different from some of the other vaccines now widely used, which include genetic instructions for the body to make its own spike protein.
The Novavax vaccine can be stored in standard refrigerators, making it easier to distribute.
Novavax delays timeline for approval, production of COVID-19 vaccine to late 2021 - National | Globalnews.ca
In February, Prime Minister Justin Trudeau announced Canada had signed a deal with Novavax to produce vaccines at a newly built facility in Montreal, though that will not be operational until towards the end of the year.
Health Canada is currently conducting a “rolling review” of the vaccine as Novavax submits data from ongoing trials.
Novavax publishes COVID-19 vaccine contract with Canada - The Globe and Mail
Novavax COVID-19 vaccine - Wikipedia
What is Novavax and what do moths have to do with producing the non-mRNA vaccine? - CNA (channelnewsasia.com)
What is the Novavax vaccine and how is it different from other vaccines being used now? Here's what we know so far:
PROTEIN-BASED VACCINE
Novavax calls its approach recombinant nanoparticle vaccine technology, it has also been called a protein sub-unit vaccine.
The technology has been in use for two decades to make vaccines, including for whooping cough and shingles.
According to a CNN report, Novavax clones a modified version of the gene for the COVID-19 virus spike protein into a baculovirus that infects insects.
Scientists then infect moth cells with that virus, spurring them to produce the coronavirus spike protein. These virus-like nanoparticles are harvested to make the vaccine.
Sinovac uses the whole, deactivated virus, while vector vaccines, like AstraZeneca, use an adenovirus to carry genetic instructions for the human body to make the spike protein. mRNA vaccines like Pfizer-BioNTech and Moderna use pieces of genetic material called messenger RNA to instruct cells to make a piece of the coronavirus spike protein.
All of them have the same purpose - to stimulate the body to produce an immune response to the virus without actually causing illness.
The main difference between Novavax and the mRNA or vector vaccines is that it is made with lab-grown copies of the COVID-19 spike protein, whereas vector and mRNA vaccines include genetic instructions for the body to make its own spike protein.
Novavax requires two doses given 21 days apart and the vaccine is stable at 2 to 8 deg Celsius, which are standard refrigerator temperatures. This means that it will be easier to store and transport for low and middle-income countries.
HIGH EFFICACY
The Novavax jab is about 90 per cent effective against COVID-19 across a variety of variants of the virus.
In Phase 3 trials in the UK earlier this year, it was 89.3 per cent effective at preventing COVID-19 and around 86 per cent effective at protecting against the Alpha variant from the UK.
It was 95.6 per cent effective against the original COVID-19 strain.
In a late-stage study in the United States and Mexico, it was more than 93 per cent effective against the predominant virus variants of concern.
It has shown far less efficacy against the Beta variant at about 55 per cent among HIV-negative people in a trial in South Africa.
However, it is 100 per cent effective at preventing moderate and severe disease, similar to other approved vaccines.
FEWER SIDE EFFECTS
Novavax has said that the vaccine was generally well-tolerated among participants.
Side effects included headache, fatigue and muscle pain and were generally mild. A small number of participants experienced side effects described as severe.
Data showed that about 40 per cent of people who received Novavax reported fatigue after the second dose, as compared with 65 per cent for Moderna and more than 55 per cent for Pfizer, the Atlantic said.
VACCINE PRODUCTION
According to news reports, the vaccine has taken longer to complete trials and ramp up production because the US company has faced operational issues.
It is small compared to the pharmaceutical giants that have had their vaccines approved so far.
However, it has now got the funding and manufacturing partners to ramp up production.
South Korea's SK Bioscience was reported to begin manufacturing Novavax COVID-19 vaccines in June and the Serum Institute of India is also supposed to make millions of doses of the Novavax shot, known there as Covovax, for the WHO-backed COVAX scheme.
What is Novavax and what do moths have to do with producing the non-mRNA vaccine? - CNA (channelnewsasia.com)
Novavax says COVID-19 vaccine highly effective in trials | CBC News
Mostly mild side effects
Side effects were mostly mild — tenderness and pain at the injection site. There were no reports of unusual blood clots or heart problems, Erck said.
Novavax reported the results in a press release and plans to publish in a medical journal, where it will be vetted by independent experts. The Maryland-based company previously released findings from smaller studies in Britain and South Africa.
COVID-19 vaccines train the body to recognize the coronavirus, especially the spike protein that coats it, and get ready to fight the virus off. The Novavax vaccine is made with lab-grown copies of that protein. That's different from some of the other vaccines now widely used, which include genetic instructions for the body to make its own spike protein.
The Novavax vaccine can be stored in standard refrigerators, making it easier to distribute.
Novavax delays timeline for approval, production of COVID-19 vaccine to late 2021 - National | Globalnews.ca
In February, Prime Minister Justin Trudeau announced Canada had signed a deal with Novavax to produce vaccines at a newly built facility in Montreal, though that will not be operational until towards the end of the year.
Health Canada is currently conducting a “rolling review” of the vaccine as Novavax submits data from ongoing trials.
Novavax publishes COVID-19 vaccine contract with Canada - The Globe and Mail
