Go ahead, take it. You might end up like this couple: https://www.usatoday.com/story/news/health/2020/03/24/coronavirus-arizona-man-dies-after-self-medicating-chloroquine/2905841001/
Getting hydroxychloroquine
- Thread starter Spacealien2
- Start date
I was speaking to someone about this just to get an idea how crazy this has gone
He said a friend of his whose a well known ophthalmologist literally woke up to death threats via voicemails texts email why? Someone made a fake abstract from NEJM with this guys name on it as primary author on a study saying this drug doesent work and passed it around social media. He’s q private ophthalmologist and wasn’t involved in any studies the image was fake.
Point is this has gone beyond the realm of science and medicine and is now in the realm of politics. Anything you hear about it is now automatically tainted. I fear the same happening when a real cure comes if one group of the political spectrum labels it as a hoax then how will we respond? This is a time we need to look at primary data and scientist and just let them what they do best
He said a friend of his whose a well known ophthalmologist literally woke up to death threats via voicemails texts email why? Someone made a fake abstract from NEJM with this guys name on it as primary author on a study saying this drug doesent work and passed it around social media. He’s q private ophthalmologist and wasn’t involved in any studies the image was fake.
Point is this has gone beyond the realm of science and medicine and is now in the realm of politics. Anything you hear about it is now automatically tainted. I fear the same happening when a real cure comes if one group of the political spectrum labels it as a hoax then how will we respond? This is a time we need to look at primary data and scientist and just let them what they do best
Really, you guys should stop spreading bs. We live in the age of internet- you can crosscheck anything you want. These knuckleheads didn't take hydroxychloroquine. The took similarly sounding aquarium cleaner.
I'm sorry, but I find your repeated use of the word "cure" in various posts to show some bias.
Do you really honestly think we will have a "cure" for COVID-19? Vaccines aren't really cures. We don't have cures for many cancers. I don't believe we have a cure for AIDS. What we have is various treatments sometimes used in combination that hopefully give the patient a chance to fight the disease.
I stand corrected cure is perhaps not the best word but I used it because I see it used often by those who are in blind support of this drug. Vaccines aren’t a cure but they certainly will alleviate the burden of the disease. All I am saying is that this drug at most has a small impact and it is being overblown. The bias is when something is supported by one side of the political aisle and not by the other as it is with this drug. That’s when you know strong advocates for either side potentially have other motives.
I think that there is a chance that this drug actually does have some benifit and when the evidence for that comes via the proper channels ie not some GP at a nursing home or a post on a forum from an alt right website I would be in support of it 100% since we don’t have anything else. It’s just I have seen and studied these things and am less optimistic about this drug , it has been tried literally on every single infection with early mixed results. I’m more excited about other novel therapies that are in the pipelines.
It’s funny UofT UHN and other academic centres in GTA have opened up grant applications for study proposals to the public and they were literally getting flooded by armchair scientist with no previous trial experience trying to study this drug and when they don’t get funding they will cry conspiracy.
The thread listed many reports of success with this drug, as i said.
Name one. I've already directed you towards much evidence of the opposite conclusion.
Irrelevant. They didn't take the drug under consideration in this topic, but some fish tank substance.
And i have no intention of getting infected with COVID-19, let alone taking this drug to treat it, even if i could obtain it in Canada, outside of it being prescribed by a doctor.
Much evidence? Evidence posted online in news articles or forums when it comes to efficiacy of medications is irrelevant. Lets stick to peer-reviewed scientific evidence? Il try...
First of all I am NOT against HCQ, all I am saying is that people with political bias are rallying for it prematurely they may be correct but lets just wait for more evidence.
There are a number of in vitro (pre-clinical) studies which I will not cite but lets focus on the two big in- vivo papers on this
Chen et al.
This trial is well designed.
Methods:
30 patients positive for COVID total who were randomized to treatment group of HCQ 400mg for 5 days vs. standard supportive care in treatment group. Results were blinded. Primary outcome was NPP swab at day 7. Secondary outcomes were imaging findings, mortality and adverse events.
Results:
The intention-to-treat analysis revealed that the treatment group did not differ from the control group in the number of patients testing negative for COVID-19 on Day 7 (13 versus 14 patients), nor the duration of illness (all P>0.05).
Conclusion:
Inconclusive evidence.
Gautret et al
This study started off strong in its design but the authors failed to withhold their methodology, patients were moved from randomized groups and new therapies were added half way. Also the primary author is a very controvercial figure. Either way the results were promising
Methods:
open-label, non-randomised controlled trial with 36 patients diagnosed with COVID-19, of which six were asymptomatic, 22 had upper respiratory tract infection symptoms, and eight had lower respiratory tract infection symptoms
The twenty patients in the treatment group received HCQ 200mg three times a day for 10 days. Patients declining to take part in the study and not meeting the inclusion criteria were assigned to the control group and received usual care
outcome was polymerase chain reaction (PCR) of SARS-CoV-2 ribonucleic acid (RNA) on nasopharyngeal swabs on day 6.
Results:
Patients in the treatment group were significantly more likely to test negative for SARS-CoV-2 on Day 6 than control
Conclusions: This is preliminary results calling for more to be studied. The MAIN thing people fail to conclude that the authors themselves acknowledge is that their outcome was VIRAL load at day 6 which does not necessarily correlate to clinical findings but it is promising. The study according to the authors themselves was not statistically powered to make inferences but they stopped it early to raise awareness.
Since these two trials there are over 80 clinical trails now registered to study this drug, some are trickeling their findings but none has come out with a smoking gun in either direction. This drug isnt without risk though and untill more evidence comes people shouldn just blindingly start taking it because of what a politician has said based on a non-randomzied non controlled statistically under powered study looking at viral load on day 6.
Adverse events:
serious cutaneous adverse reactions
Fulminant hepatic failure
ventricular arrhythmias (especially when prescribed with azithromycin)
overdose is hazardous and difficult to treat.
Which is why doctors prescribe medication to treat a disease, not because maybe it might have something to do with a disease you don't have.
If Trump had not said anything about hydroxychloroquine, or said that it needs more trials and testing, the media would be tearing him a new asshole for denying life saving treatment to countless people. We all know the narrative is to be anti-Trump 24/7/366.
Here’s an idea. All the naysayers, when you’re in the hospital fighting to breathe, feel free to turn down this drug since it hasn’t been through a double blind placebo study. That’s your right.
I should have the right to take it if I want, and if you don’t like it, kick rocks.
Life can be so simple.
Here’s an idea. All the naysayers, when you’re in the hospital fighting to breathe, feel free to turn down this drug since it hasn’t been through a double blind placebo study. That’s your right.
I should have the right to take it if I want, and if you don’t like it, kick rocks.
Life can be so simple.
Liberal Treated With Hydroxychloroquine Hopes He Still Dies Of COVID-19 To Prove Trump Is Stupid
https://babylonbee.com/news/liberal...ill-dies-of-covid-19-to-prove-trump-is-stupid
https://babylonbee.com/news/liberal...ill-dies-of-covid-19-to-prove-trump-is-stupid
I am 100% agreement with you on this! The naysayers you can refuse it! You realized that it only work if you take early as soon as you suspect you have covid-19 it lead to a better outcome of the disease.
The problem every single country wants it ... just like situations with PPE. Limited supply and India controls the supply! They need for their own uses!
Go to video: 17:17
India Bans Exports Of Trump's "Game Changer" Anti-COVID-19 Drug
After initially declaring that he wouldn't use the DPA because American companies were doing the right thing and accelerating production of ventilators and other critical supplies on their own - Trump said that with a straight face while Elon Musk turned in a batch of Tesla-made "ventilators" that turned out to be CPAP machines - President Trump became embroiled in what has become by all accounts a nasty feud with 3M, a Dow constituent and pillar of American industry.
After Trump accused the company for being "unpatriotic" and risking American lives by choosing to honor contracts promising deliveries of critical medical supplies to customers abroad instead of turning them over to hospitals in the US, its CEO appeared on CNBC Friday to try and explain why its decision would save more lives in the long run because it would surely prompt other countries to respond in-kind. And given 3M's complex, international supply chain, this could jeopardize the company's ability to continue providing its products to the US.
Many of Trump's critics blasted the president for appearing to scapegoat a vital American corporation for the administration's flat-footed response to the outbreak, and repeated some version of the argument outlined above. And while their arguments are certainly based on a reasonable foundation, they've neglected to mention one critical fact: Other countries are already doing the same thing to the US. Many Chinese factories have stopped delivering products from masks and gloves all the way to widely used drugs. And now, after earlier restricting its export to purely "humanitarian" grounds (as if there was any other reason for the use of medicine), New Delhi is banning export of hydroxychloroquine, a malaria drug that Trump once touted as a “game changer”, and which has recently proved effective at combating some of the virus's deadliest symptoms.
According to Bloomberg, https://www.bloomberg.com/news/arti...changer-virus-drug?srnd=premium&sref=2WWyrgO6
exports of the drug and its formulations are now being prohibited "without any exceptions" and with immediate effect, according to India’s Directorate General of Foreign Trade. The statement is dated April 4.
Trump raised the issue of India's decision to restrict export of the drug up during Saturday's press conference. He claimed that he had appealed directly to Indian Prime Minister Narendra Modi for already-ordered shipments of the drug to be released to the US
India is giving his request “serious consideration,” the president said.
Trump says the federal government is stockpiling millions of doses of the drug to make it available for coronavirus patients. And fortunately, it's not the only drug that has shown to be effective in treating COVID-19 Japanese PM Shinzo Abe recently ordered apanese drugmakers to ramp up production of Avigan, a drug Abe believes to be quite effective. Antivirals like Gilead's Remdesivir have also shown effectiveness and are also being studied.
Professor Didier Raoult Releases the Results of a New Hydroxychloroquine Treatment Study on 1061 Patients
http://covexit.com/professor-didier...chloroquine-treatment-study-on-1061-patients/
http://covexit.com/professor-didier...chloroquine-treatment-study-on-1061-patients/
